North American Registry of Midwives (NARM) Practice Exam

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What is the most common symptom of Human cytomegalovirus (HCMV) infection?

Severe headache
Fever and muscle pain
Chronic cough
Skin rash

The correct answer is: Fever and muscle pain

Fever and muscle pain are indeed the most common symptoms of Human cytomegalovirus (HCMV) infection. HCMV is a member of the herpesvirus family and often leads to symptomatic presentations primarily in individuals with weakened immune systems or in newborns. The initial phase of HCMV infection can resemble mononucleosis, which typically includes symptoms like fever, muscle aches, and fatigue. Other symptoms associated with HCMV may include swollen glands and malaise, but the combination of fever and muscle pain is most frequently reported. While severe headache, chronic cough, and skin rash can occur with various viral infections, they are not specific to HCMV and are less prevalent in its symptomatic presentations. Thus, the presence of fever and muscle pain serves as a key indicator of HCMV infection.